The HFE2 Antibody (C-term) from MyBioSource.com is a Rabbit Polyclonal antibody to Hemojuvelin, HFE2, HJV, JH, and RGMc. This antibody recognizes Human, and Rat antigen. The HFE2 Antibody (C-term) has been validated for the following applications: ELISA, Flow Cytometry, and Western Blot.
Description
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30